What are the symptoms of Primary Central Nervous System (CNS) lymphoma? You may have experienced some of these symptoms before. However, if you're having trouble identifying these symptoms, you should seek medical attention right away. Read on to learn more about these symptoms. They may be similar to others or differ depending on where the cancer is located. Listed below are the most common signs and symptoms of Primary Central Nervous System Lymphoma.
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The treatment for primary central nervous system lymphoma will depend on whether the cancer has spread beyond the cerebrum, the largest part of the brain. The patient should be under 60 years old, be able to maintain their daily functions, and be free of AIDS or any other diseases that weaken the immune system. Although CNS lymphoma symptoms may improve quickly after treatment, a full recovery may not occur. In such cases, your medical team may refer you to a rehabilitation specialist.
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For suspected cases, patients may undergo diagnostic tests. Blood tests may show a low level of red blood cells. Your doctor will also run blood tests to detect abnormalities in your white blood cells and platelets. Your blood is also tested for HIV and other conditions, which may be associated with the cancer. A biopsy is also recommended if the lymphoma is present in the brain. Once a diagnosis is made, treatment will begin.
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In addition to examining your blood, you'll need to undergo some tests to confirm whether you have this type of lymphoma. HIV infection is one of the main risk factors for primary CNS lymphoma, so being positive for HIV antibodies is essential to prevent this disease. However, HIV antibodies can take six months to become positive. If the test results are negative, your doctor may suggest other treatments that may be appropriate for you.
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The most common symptom of primary CNS lymphoma is progressive myelopathy, which most patients present with in the seventh decade of life. Sixty-four percent of patients also have a constitutional illness associated with the lymphoma. Of these patients, 29 percent suffered back pain, while 43 percent reported lower motor neuron signs such as flaccid paralysis. The tumor may be in the frontal lobe or corpus callosum, but this does not preclude an infection.
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Although the first line treatment is effective, most patients relapse within two years. This happens because of a relapse of the disease from occult lymphoma cells that are still present in the brain. The symptoms of PCNSL may not be readily noticeable to the patient. However, the best way to detect and manage PCNSL is to visit your doctor as soon as you notice any of these symptoms.
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Treatment for primary CNS lymphoma varies widely. The cornerstone of treatment for the disease is high-dose methotrexate, which is cleared by the kidneys. Patients may be required to undergo multiple follow-up tests to ensure the treatment is working. It is important to note that treatment for this type of lymphoma is still difficult, and some treatment options may have side effects.
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While primary CNS lymphoma is rare, it is often associated with substantial morbidity and mortality. It is more prevalent in the elderly, HIV-positive population, and post-transplant patients. While treatment for primary CNS lymphoma is similar to that for other types of cancer, the prognosis for primary CNS lymphoma is different. During treatment, the risk of relapse is lower if the cancer has spread outside the CNS.
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Other symptoms of Primary Central Nervous System Lymphoma are leptomeningeal lesions, ocular/vitreoretinal lesions, and spinal cord involvement. Neurolymphomatosis, also known as peripheral nerve lymphoma, is characterized by predominantly B-cell origin. While it is possible to develop primary CNSL from a T-cell subtype, the disease is usually characterized by increased B-symptoms and decreased ocular involvement.
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In patients with primary CNS lymphoma, treatment options include surgery, radiation therapy, or chemotherapy. Steroid therapy reduces the swelling around the tumour and may even shrink it. Chemotherapy involves administering a drug through a vein or into the fluid surrounding the brain. Similarly, radiotherapy uses high-energy rays to destroy cancerous cells. The latter may be used in combination with chemotherapy, resulting in a more aggressive treatment.
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High-grade peripheral T-cell lymphoma is rare and usually affects a small percentage of patients with this disease. It has different symptoms and treatment options than B-cell lymphoma. A high-grade lymphoma may cause a person to have chronic pain and even experience paralyzed organs. However, the most common symptoms of PCNSL include:
